A composite MyD88/CD40 switch synergistically activates mouse and human dendritic cells for enhanced antitumor efficacy

The in vivo therapeutic efficacy of DC-based cancer vaccines is limited by suboptimal DC maturation protocols. Although delivery of TLR adjuvants systemically boosts DC-based cancer vaccine efficacy, it could also increase toxicity. Here, we have engineered a drug-inducible, composite activation rec...

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Библиографические подробности
Главные авторы: Narayanan, Priyadharshini, Lapteva, Natalia, Seethammagari, Mamatha, Levitt, Jonathan M., Slawin, Kevin M., Spencer, David M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2011
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069772/
https://ncbi.nlm.nih.gov/pubmed/21383499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44327
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