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MyD88/CD40 signaling retains CAR T cells in a less differentiated state
Chimeric antigen receptor (CAR) T cell therapy for solid tumors has shown limited efficacy in early-phase clinical studies. The majority of CARs encode CD28 and/or 41BB costimulatory endodomains, and we explored whether MyD88 and CD40 (MC) costimulatory endodomains in CARs could improve their antitu...
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| 出版年: | JCI Insight |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2020
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7710311/ https://ncbi.nlm.nih.gov/pubmed/33148882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136093 |
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