MyD88/CD40 signaling retains CAR T cells in a less differentiated state

Chimeric antigen receptor (CAR) T cell therapy for solid tumors has shown limited efficacy in early-phase clinical studies. The majority of CARs encode CD28 and/or 41BB costimulatory endodomains, and we explored whether MyD88 and CD40 (MC) costimulatory endodomains in CARs could improve their antitu...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Prinzing, Brooke, Schreiner, Patrick, Bell, Matthew, Fan, Yiping, Krenciute, Giedre, Gottschalk, Stephen
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710311/
https://ncbi.nlm.nih.gov/pubmed/33148882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136093
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