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Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
On-target/off-tumor toxicity is one of the major concerns regarding CAR T-cell therapy. Kosti et al.(1) demonstrate that this form of toxicity can be prevented by designing a CAR whose expression is controlled by oxygen levels in the tumor environment.
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| Veröffentlicht in: | Cell Rep Med |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8080122/ https://ncbi.nlm.nih.gov/pubmed/33948575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2021.100244 |
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