A carregar...
MyD88/CD40 signaling retains CAR T cells in a less differentiated state
Chimeric antigen receptor (CAR) T cell therapy for solid tumors has shown limited efficacy in early-phase clinical studies. The majority of CARs encode CD28 and/or 41BB costimulatory endodomains, and we explored whether MyD88 and CD40 (MC) costimulatory endodomains in CARs could improve their antitu...
Na minha lista:
| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2020
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7710311/ https://ncbi.nlm.nih.gov/pubmed/33148882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136093 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|