5-HT(1B) RECEPTOR-MEDIATED ACTIVATION OF ERK1/2 REQUIRES BOTH Gα(i/o) AND β-ARRESTIN PROTEINS

5-HT(1B) receptors modulate synaptic serotonin (5-HT) levels and play a significant role in the regulation of emotional behaviors. These receptors are Gα(i/o)-coupled and inhibit adenylyl cyclase but have also been reported to activate MAP kinases; however, the details of signaling cascades downstre...

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Détails bibliographiques
Publié dans:ACS Chem Neurosci
Auteurs principaux: Liu, Yusha, Gibson, Alec W., Levinstein, Marjorie R., Lesiak, Atom J., Ong, Shao-En, Neumaier, John F.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217031/
https://ncbi.nlm.nih.gov/pubmed/30946562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00596
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