MEK1 Binds Directly to βArrestin1, Influencing Both Its Phosphorylation by ERK and the Timing of Its Isoprenaline-stimulated Internalization

βArrestin is a multifunctional signal scaffold protein. Using SPOT immobilized peptide arrays, coupled with scanning alanine substitution and mutagenesis, we show that the MAPK kinase, MEK1, interacts directly with βarrestin1. Asp(26) and Asp(29) in the N-terminal domain of βarrestin1 are critical f...

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Bibliografski detalji
Glavni autori: Meng, Dong, Lynch, Martin J., Huston, Elaine, Beyermann, Michael, Eichhorst, Jenny, Adams, David R., Klussmann, Enno, Houslay, Miles D., Baillie, George S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Mechanisms of Signal Transduction
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670148/
https://ncbi.nlm.nih.gov/pubmed/19153083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806395200
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