MEK1 Binds Directly to βArrestin1, Influencing Both Its Phosphorylation by ERK and the Timing of Its Isoprenaline-stimulated Internalization

βArrestin is a multifunctional signal scaffold protein. Using SPOT immobilized peptide arrays, coupled with scanning alanine substitution and mutagenesis, we show that the MAPK kinase, MEK1, interacts directly with βarrestin1. Asp(26) and Asp(29) in the N-terminal domain of βarrestin1 are critical f...

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Detalhes bibliográficos
Main Authors: Meng, Dong, Lynch, Martin J., Huston, Elaine, Beyermann, Michael, Eichhorst, Jenny, Adams, David R., Klussmann, Enno, Houslay, Miles D., Baillie, George S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670148/
https://ncbi.nlm.nih.gov/pubmed/19153083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806395200
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