Focal and generalized seizure activity after local hippocampal or cortical ablation of Na(V)1.1 channels in mice

Early onset seizures are a hallmark of Dravet syndrome. Previous studies in rodent models have shown that the epileptic phenotype is caused by loss‐of‐function of voltage‐gated Na(V)1.1 sodium channels, which are chiefly expressed in γ‐aminobutyric acid (GABA)ergic neurons. Recently, a possibly crit...

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Detalhes bibliográficos
Publicado no:Epilepsia
Main Authors: Jansen, Nico A., Dehghani, Anisa, Breukel, Cor, Tolner, Else A., van den Maagdenberg, Arn M. J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216883/
https://ncbi.nlm.nih.gov/pubmed/32190912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.16482
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