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CaV2.1 ablation in cortical interneurons selectively impairs fast-spiking basket cells and causes generalized seizures
BACKGROUND: Both the neuronal populations and mechanisms responsible for generalized spike-wave absence seizures are poorly understood. In mutant mice carrying loss-of-function mutations in Cacna1a, which encodes the α1 pore-forming subunit of Ca(V)2.1 (P/Q-type) voltage-gated Ca(2+) channels, gener...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3849346/ https://ncbi.nlm.nih.gov/pubmed/23595603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23913 |
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