A conserved mito-cytosolic translational balance links two longevity pathways

Slowing down translation in either the cytosol or the mitochondria are conserved longevity mechanisms. Here, we found a non-interventional natural correlation of mitochondrial and cytosolic ribosomal proteins (RPs) in mouse population genetics, suggesting a translational balance. Inhibiting mitochon...

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Publicat a:Cell Metab
Autors principals: Molenaars, Marte, Janssens, Georges E., Williams, Evan G., Jongejan, Aldo, Lan, Jiayi, Rabot, Sylvie, Joly, Fatima, Moerland, Perry D., Schomakers, Bauke V., Lezzerini, Marco, Liu, Yasmine J., McCormick, Mark A., Kennedy, Brian K., van Weeghel, Michel, van Kampen, Antoine H.C., Aebersold, Ruedi, MacInnes, Alyson W., Houtkooper, Riekelt H.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214782/
https://ncbi.nlm.nih.gov/pubmed/32084377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.01.011
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