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Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation
Mutations in the clk-1 gene impair mitochondrial ubiquinone biosynthesis and extend the lifespan in Caenorhabditis elegans. We demonstrate here that this life extension is linked to the repression of cytoplasmic mRNA translation, independent of the alleged nuclear form of CLK-1. Clk-1 mutations inhi...
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| Veröffentlicht in: | Life Sci Alliance |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Life Science Alliance LLC
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6126614/ https://ncbi.nlm.nih.gov/pubmed/30198021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800082 |
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