Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation

Mutations in the clk-1 gene impair mitochondrial ubiquinone biosynthesis and extend the lifespan in Caenorhabditis elegans. We demonstrate here that this life extension is linked to the repression of cytoplasmic mRNA translation, independent of the alleged nuclear form of CLK-1. Clk-1 mutations inhi...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Life Sci Alliance
Egile Nagusiak: Molenaars, Marte, Janssens, Georges E, Santermans, Toon, Lezzerini, Marco, Jelier, Rob, MacInnes, Alyson W, Houtkooper, Riekelt H
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Life Science Alliance LLC 2018
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126614/
https://ncbi.nlm.nih.gov/pubmed/30198021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800082
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