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Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation

Mutations in the clk-1 gene impair mitochondrial ubiquinone biosynthesis and extend the lifespan in Caenorhabditis elegans. We demonstrate here that this life extension is linked to the repression of cytoplasmic mRNA translation, independent of the alleged nuclear form of CLK-1. Clk-1 mutations inhi...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Molenaars, Marte, Janssens, Georges E, Santermans, Toon, Lezzerini, Marco, Jelier, Rob, MacInnes, Alyson W, Houtkooper, Riekelt H
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126614/
https://ncbi.nlm.nih.gov/pubmed/30198021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800082
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