Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30

Mitochondrial form and function are closely interlinked in homeostasis and aging. Inhibiting mitochondrial translation is known to increase lifespan in C. elegans, and is accompanied by a fragmented mitochondrial network. However, whether this link between mitochondrial translation and morphology is...

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Pubblicato in:J Cell Biol
Autori principali: Liu, Yasmine J., McIntyre, Rebecca L., Janssens, Georges E., Williams, Evan G., Lan, Jiayi, van Weeghel, Michel, Schomakers, Bauke, van der Veen, Henk, van der Wel, Nicole N., Yao, Pallas, Mair, William B., Aebersold, Ruedi, MacInnes, Alyson W., Houtkooper, Riekelt H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265311/
https://ncbi.nlm.nih.gov/pubmed/32259199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201907067
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