Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling

Pressure overload (PO) cardiac hypertrophy and heart failure are associated with generalized insulin resistance and hyperinsulinemia, which may exacerbate left ventricular (LV) remodeling. While PO activates insulin receptor tyrosine kinase activity that is transduced by insulin receptor substrate 1...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Riehle, Christian, Weatherford, Eric T., Wende, Adam R., Jaishy, Bharat P., Seei, Alec W., McCarty, Nicholas S., Rech, Monika, Shi, Qian, Reddy, Gopireddy R., Kutschke, William J., Oliveira, Karen, Pires, Karla Maria, Anderson, Joshua C., Diakos, Nikolaos A., Weiss, Robert M., White, Morris F., Drakos, Stavros G., Xiang, Yang K., Abel, E. Dale
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213803/
https://ncbi.nlm.nih.gov/pubmed/32213702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134920
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