Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling

Pressure overload (PO) cardiac hypertrophy and heart failure are associated with generalized insulin resistance and hyperinsulinemia, which may exacerbate left ventricular (LV) remodeling. While PO activates insulin receptor tyrosine kinase activity that is transduced by insulin receptor substrate 1...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Riehle, Christian, Weatherford, Eric T., Wende, Adam R., Jaishy, Bharat P., Seei, Alec W., McCarty, Nicholas S., Rech, Monika, Shi, Qian, Reddy, Gopireddy R., Kutschke, William J., Oliveira, Karen, Pires, Karla Maria, Anderson, Joshua C., Diakos, Nikolaos A., Weiss, Robert M., White, Morris F., Drakos, Stavros G., Xiang, Yang K., Abel, E. Dale
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213803/
https://ncbi.nlm.nih.gov/pubmed/32213702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134920
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