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Insulin Receptor Substrates Are Essential for the Bioenergetic and Hypertrophic Response of the Heart to Exercise Training

Insulin and insulin-like growth factor 1 (IGF-1) receptor signaling pathways differentially modulate cardiac growth under resting conditions and following exercise training. These effects are mediated by insulin receptor substrate 1 (IRS1) and IRS2, which also differentially regulate resting cardiac...

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Autors principals: Riehle, Christian, Wende, Adam R., Zhu, Yi, Oliveira, Karen J., Pereira, Renata O., Jaishy, Bharat P., Bevins, Jack, Valdez, Steven, Noh, Junghyun, Kim, Bum Jun, Moreira, Annie Bello, Weatherford, Eric T., Manivel, Rajkumar, Rawlings, Tenley A., Rech, Monika, White, Morris F., Abel, E. Dale
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135616/
https://ncbi.nlm.nih.gov/pubmed/25002528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00426-14
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