Insulin Receptor Substrates Are Essential for the Bioenergetic and Hypertrophic Response of the Heart to Exercise Training

Insulin and insulin-like growth factor 1 (IGF-1) receptor signaling pathways differentially modulate cardiac growth under resting conditions and following exercise training. These effects are mediated by insulin receptor substrate 1 (IRS1) and IRS2, which also differentially regulate resting cardiac...

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Main Authors: Riehle, Christian, Wende, Adam R., Zhu, Yi, Oliveira, Karen J., Pereira, Renata O., Jaishy, Bharat P., Bevins, Jack, Valdez, Steven, Noh, Junghyun, Kim, Bum Jun, Moreira, Annie Bello, Weatherford, Eric T., Manivel, Rajkumar, Rawlings, Tenley A., Rech, Monika, White, Morris F., Abel, E. Dale
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135616/
https://ncbi.nlm.nih.gov/pubmed/25002528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00426-14
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