Aberrant expression of the COX2/PGE(2) axis is induced by activation of the RAF/MEK/ERK pathway in BRAF(V595E) canine urothelial carcinoma

Cancer-promoting inflammation is an important event in cancer development. Canine urothelial carcinoma (cUC) overexpresses prostaglandin E(2) (PGE(2)) and has a unique sensitivity to cyclooxygenase 2 (COX2)-inhibiting therapy. In addition, majority of cUC harbour BRAF(V595E) mutation. However, mecha...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yoshitake, Ryohei, Saeki, Kohei, Eto, Shotaro, Shinada, Masahiro, Nakano, Rei, Sugiya, Hiroshi, Endo, Yoshifumi, Fujita, Naoki, Nishimura, Ryohei, Nakagawa, Takayuki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210937/
https://ncbi.nlm.nih.gov/pubmed/32385388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64832-5
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados