Aberrant expression of the COX2/PGE(2) axis is induced by activation of the RAF/MEK/ERK pathway in BRAF(V595E) canine urothelial carcinoma

Cancer-promoting inflammation is an important event in cancer development. Canine urothelial carcinoma (cUC) overexpresses prostaglandin E(2) (PGE(2)) and has a unique sensitivity to cyclooxygenase 2 (COX2)-inhibiting therapy. In addition, majority of cUC harbour BRAF(V595E) mutation. However, mecha...

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Publicat a:Sci Rep
Autors principals: Yoshitake, Ryohei, Saeki, Kohei, Eto, Shotaro, Shinada, Masahiro, Nakano, Rei, Sugiya, Hiroshi, Endo, Yoshifumi, Fujita, Naoki, Nishimura, Ryohei, Nakagawa, Takayuki
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210937/
https://ncbi.nlm.nih.gov/pubmed/32385388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64832-5
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