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BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association
Expression of aberrantly spliced BRAF V600E isoforms (BRAF V600E ΔEx) mediates resistance in 13%–30% of melanoma patients progressing on RAF inhibitors. BRAF V600E ΔEx confers resistance, in part, through enhanced dimerization. Here, we uncoupled BRAF V600E ΔEx dimerization from maintenance of MEK-E...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6261462/ https://ncbi.nlm.nih.gov/pubmed/30404005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.049 |
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