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Inhibition of mutant BRAF splice variant signaling by next generation, selective RAF inhibitors
Vemurafenib and dabrafenib block MEK-ERK1/2 signaling and cause tumor regression in the majority of advanced-stage BRAF(V600E) melanoma patients; however, acquired resistance and paradoxical signaling have driven efforts for more potent and selective RAF inhibitors. Next generation RAF inhibitors, s...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3988223/ https://ncbi.nlm.nih.gov/pubmed/24422853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12218 |
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