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Downregulation of Noxa by RAF/MEK inhibition counteracts cell death response in mutant B-RAF melanoma cells

FDA approval of new therapies in 2011 has greatly expanded the treatment options for metastatic melanoma. Patients with V600 mutant v-raf murine sarcoma viral oncogene homolog B1 (B-RAF) positive metastatic melanoma are now treated with the RAF inhibitor, vemurafenib (Zelboraf) as a first line thera...

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Bibliografiske detaljer
Main Authors: Basile, Kevin J, Aplin, Andrew E
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512187/
https://ncbi.nlm.nih.gov/pubmed/23226618
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