TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF-Mutant Melanoma

RAF and MEK (mitogen-activated or extracellular signal–regulated protein kinase kinase) inhibitors are effective in treating patients with BRAF-mutant melanoma. However, most responses are partial and short-lived, and many patients fail to respond at all. We found that suppression of TORC1 activity...

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Main Authors: Corcoran, Ryan B., Rothenberg, Stephen Michael, Hata, Aaron N., Faber, Anthony C., Piris, Adriano, Nazarian, Rosalynn M., Brown, Ronald D., Godfrey, Jason T., Winokur, Daniel, Walsh, John, Mino-Kenudson, Mari, Maheswaran, Shyamala, Settleman, Jeffrey, Wargo, Jennifer A., Flaherty, Keith T., Haber, Daniel A., Engelman, Jeffrey A.
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867020/
https://ncbi.nlm.nih.gov/pubmed/23903755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005753
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