SUN-221 Subclinical Alpha-1 Antitrypsin Deficiency Is Associated with Increased Free Cortisol Fraction in Plasma and Altered Glucocorticoid Delivery to Tissues

Background Corticosteroid Binding Globulin (CBG) binds >85% of plasma cortisol and controls the circulating free cortisol pool. Proteolytic cleavage by neutrophil elastase is proposed to reduce CBG binding affinity and increase free cortisol availability to inflamed tissues. The CORtisol NETwork...

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Dettagli Bibliografici
Pubblicato in:J Endocr Soc
Autori principali: Boyle, Luke David, Nixon, Mark, Underhill, Caroline M, Hill, Lesley A, Homer, Natalie Z M, Andrew, Ruth, Hammond, Geoffrey L, Lewis, John G, Stimson, Roland H, Walker, Brian Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Adrenal
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208476/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1849
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