SUN-221 Subclinical Alpha-1 Antitrypsin Deficiency Is Associated with Increased Free Cortisol Fraction in Plasma and Altered Glucocorticoid Delivery to Tissues

Background Corticosteroid Binding Globulin (CBG) binds >85% of plasma cortisol and controls the circulating free cortisol pool. Proteolytic cleavage by neutrophil elastase is proposed to reduce CBG binding affinity and increase free cortisol availability to inflamed tissues. The CORtisol NETwork...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Endocr Soc
Egile Nagusiak: Boyle, Luke David, Nixon, Mark, Underhill, Caroline M, Hill, Lesley A, Homer, Natalie Z M, Andrew, Ruth, Hammond, Geoffrey L, Lewis, John G, Stimson, Roland H, Walker, Brian Robert
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2020
Gaiak:
Adrenal
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208476/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1849
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