Substrate-based kinase activity inference identifies MK2 as driver of colitis

Inflammatory bowel disease (IBD) is a chronic and debilitating disorder that has few treatment options due to a lack of comprehensive understanding of its molecular pathogenesis. We used multiplexed mass spectrometry to collect high-content information on protein phosphorylation in two different mou...

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Veröffentlicht in:Integr Biol (Camb)
Hauptverfasser: Strasser, Samantha Dale, Ghazi, Phaedra C., Starchenko, Alina, Boukhali, Myriam, Edwards, Amanda, Suarez-Lopez, Lucia, Lyons, Jesse, Changelian, Paul S., Monahan, Joseph B., Jacobsen, Jon, Brubaker, Douglas K., Joughin, Brian A., Yaffe, Michael B., Haas, Wilhelm, Lauffenburger, Douglas A., Haigis, Kevin M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208439/
https://ncbi.nlm.nih.gov/pubmed/31617572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intbio/zyz025
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