Integrated in vivo multi-omics analysis identifies p21-activated kinase signaling as a driver of colitis

Inflammatory bowel disease (IBD) is a chronic disorder of the gastrointestinal tract. The molecular mechanisms underlying IBD are poorly characterized and treatment options are limited. To gain insight into the pathogenesis of chronic colonic inflammation (colitis), we performed a multi-omic analysi...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Lyons, Jesse, Brubaker, Douglas K., Ghazi, Phaedra C., Baldwin, Katherine R., Edwards, Amanda, Boukhali, Myriam, Strasser, Samantha Dale, Suarez-Lopez, Lucia, Lin, Yi-Jang, Yajnik, Vijay, Kissil, Joseph L., Haas, Wilhelm, Lauffenburger, Douglas A., Haigis, Kevin M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719711/
https://ncbi.nlm.nih.gov/pubmed/29487189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aan3580
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