Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study

অনুযায়ী Gordon, David, Hellriegel, Edward T, Hope, Heidi Rath, Burt, David, Monahan, Joseph B
প্রকাশিত Clin Pharmacol (2021)

Radiation causes tissue damage by dysregulating inflammasome–gasdermin D signaling in both host and transplanted cells

অনুযায়ী Xiao, Jianqiu, Wang, Chun, Yao, Juo-Chin, Alippe, Yael, Yang, Tong, Kress, Dustin, Sun, Kai, Kostecki, Kourtney L., Monahan, Joseph B., Veis, Deborah J., Abu-Amer, Yousef, Link, Daniel C., Mbalaviele, Gabriel
প্রকাশিত PLoS Biol (2020)

Substrate-based kinase activity inference identifies MK2 as driver of colitis

অনুযায়ী Strasser, Samantha Dale, Ghazi, Phaedra C., Starchenko, Alina, Boukhali, Myriam, Edwards, Amanda, Suarez-Lopez, Lucia, Lyons, Jesse, Changelian, Paul S., Monahan, Joseph B., Jacobsen, Jon, Brubaker, Douglas K., Joughin, Brian A., Yaffe, Michael B., Haas, Wilhelm, Lauffenburger, Douglas A., Haigis, Kevin M.
প্রকাশিত Integr Biol (Camb) (2019)

Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals

অনুযায়ী Wang, Chun, Hockerman, Susan, Jacobsen, E. Jon, Alippe, Yael, Selness, Shaun R., Hope, Heidi R., Hirsch, Jeffrey L., Mnich, Stephen J., Saabye, Matthew J., Hood, William F., Bonar, Sheri L., Abu-Amer, Yousef, Haimovich, Ariela, Hoffman, Hal M., Monahan, Joseph B., Mbalaviele, Gabriel
প্রকাশিত J Exp Med (2018)

Inhibition of the stromal p38MAPK/MK2 pathway limits breast cancer metastases and chemotherapy-induced bone loss

অনুযায়ী Murali, Bhavna, Ren, Qihao, Luo, Xianmin, Faget, Douglas V., Wang, Chun, Johnson, Radia Marie, Gruosso, Tina, Flanagan, Kevin C., Fu, Yujie, Leahy, Kathleen, Alspach, Elise, Su, Xinming, Ross, Michael H., Burnette, Barry, Weilbaecher, Katherine N., Park, Morag, Mbalaviele, Gabriel, Monahan, Joseph B., Stewart, Sheila A.
প্রকাশিত Cancer Res (2018)