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Covalent Labeling with an α, β Unsaturated Carbonyl Scaffold for Studying Protein Structure and Interactions by Mass Spectrometry

A new covalent labeling (CL) reagent based on an α, β-unsaturated carbonyl scaffold has been developed for studying protein structure and protein-protein interactions when coupled with mass spectrometry. We show that this new reagent scaffold can react with up to 13 different types of residues on pr...

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Bibliografiske detaljer
Udgivet i:Anal Chem
Main Authors: Zhao, Bo, Zhuang, Jiaming, Xu, Miaowei, Liu, Tianying, Limpikirati, Patanachai, Thayumanavan, S., Vachet, Richard W.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7207043/
https://ncbi.nlm.nih.gov/pubmed/32250591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c00463
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