Heterochromatin drives compartmentalization of inverted and conventional nuclei

The mammalian cell nucleus displays a distinct spatial segregation of active euchromatic from inactive heterochromatic genomic regions(1,2). In conventional nuclei, microscopy shows that euchromatin is localized in the nuclear interior and heterochromatin at the nuclear periphery(1,2). Hi-C shows th...

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Bibliographic Details
Published in:Nature
Main Authors: Falk, Martin, Feodorova, Yana, Naumova, Natalia, Imakaev, Maxim, Lajoie, Bryan R., Leonhardt, Heinrich, Joffe, Boris, Dekker, Job, Fudenberg, Geoffrey, Solovei, Irina, Mirny, Leonid A.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206897/
https://ncbi.nlm.nih.gov/pubmed/31168090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1275-3
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