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Chromatin organization by an interplay of loop extrusion and compartmental segregation

Mammalian chromatin is spatially organized at many scales showing two prominent features in interphase: (i) alternating regions (1–10 Mb) of active and inactive chromatin that spatially segregate into different compartments, and (ii) domains (<1 Mb), that is, regions that preferentially interact...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nuebler, Johannes, Fudenberg, Geoffrey, Imakaev, Maxim, Abdennur, Nezar, Mirny, Leonid A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055145/
https://ncbi.nlm.nih.gov/pubmed/29967174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717730115
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