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Heterochromatin drives compartmentalization of inverted and conventional nuclei

The mammalian cell nucleus displays a distinct spatial segregation of active euchromatic from inactive heterochromatic genomic regions(1,2). In conventional nuclei, microscopy shows that euchromatin is localized in the nuclear interior and heterochromatin at the nuclear periphery(1,2). Hi-C shows th...

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發表在:Nature
Main Authors: Falk, Martin, Feodorova, Yana, Naumova, Natalia, Imakaev, Maxim, Lajoie, Bryan R., Leonhardt, Heinrich, Joffe, Boris, Dekker, Job, Fudenberg, Geoffrey, Solovei, Irina, Mirny, Leonid A.
格式: Artigo
語言:Inglês
出版: 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206897/
https://ncbi.nlm.nih.gov/pubmed/31168090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1275-3
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