Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer’s disease

BACKGROUND: Proteomic characterization of microglia provides the most proximate assessment of functionally relevant molecular mechanisms of neuroinflammation. However, microglial proteomics studies have been limited by low cellular yield and contamination by non-microglial proteins using existing en...

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Pubblicato in:Mol Neurodegener
Autori principali: Rayaprolu, Sruti, Gao, Tianwen, Xiao, Hailian, Ramesha, Supriya, Weinstock, Laura D., Shah, Jheel, Duong, Duc M., Dammer, Eric B., Webster, James A., Lah, James J., Wood, Levi B., Betarbet, Ranjita, Levey, Allan I., Seyfried, Nicholas T., Rangaraju, Srikant
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206797/
https://ncbi.nlm.nih.gov/pubmed/32381088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00377-5
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