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Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer’s disease

BACKGROUND: Proteomic characterization of microglia provides the most proximate assessment of functionally relevant molecular mechanisms of neuroinflammation. However, microglial proteomics studies have been limited by low cellular yield and contamination by non-microglial proteins using existing en...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Rayaprolu, Sruti, Gao, Tianwen, Xiao, Hailian, Ramesha, Supriya, Weinstock, Laura D., Shah, Jheel, Duong, Duc M., Dammer, Eric B., Webster, James A., Lah, James J., Wood, Levi B., Betarbet, Ranjita, Levey, Allan I., Seyfried, Nicholas T., Rangaraju, Srikant
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206797/
https://ncbi.nlm.nih.gov/pubmed/32381088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00377-5
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