Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects

Aging-induced structural and functional alterations of the neurovascular unit lead to impairment of neurovascular coupling responses, dysregulation of cerebral blood flow, and increased neuroinflammation, all of which contribute importantly to the pathogenesis of age-related vascular cognitive impai...

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Détails bibliographiques
Publié dans:GeroScience
Auteurs principaux: Kiss, Tamas, Nyúl-Tóth, Ádám, Balasubramanian, Priya, Tarantini, Stefano, Ahire, Chetan, Yabluchanskiy, Andriy, Csipo, Tamas, Farkas, Eszter, Wren, Jonathan D., Garman, Lori, Csiszar, Anna, Ungvari, Zoltan
Format: Artigo
Langue:Inglês
Publié: Springer International Publishing 2020
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206476/
https://ncbi.nlm.nih.gov/pubmed/32056076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00165-5
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