Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects

Aging-induced structural and functional alterations of the neurovascular unit lead to impairment of neurovascular coupling responses, dysregulation of cerebral blood flow, and increased neuroinflammation, all of which contribute importantly to the pathogenesis of age-related vascular cognitive impai...

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Publicat a:GeroScience
Autors principals: Kiss, Tamas, Nyúl-Tóth, Ádám, Balasubramanian, Priya, Tarantini, Stefano, Ahire, Chetan, Yabluchanskiy, Andriy, Csipo, Tamas, Farkas, Eszter, Wren, Jonathan D., Garman, Lori, Csiszar, Anna, Ungvari, Zoltan
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206476/
https://ncbi.nlm.nih.gov/pubmed/32056076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00165-5
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