Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice

Whole brain irradiation (WBI, also known as whole brain radiation therapy or WBRT) is a mainstream therapy for patients with identifiable brain metastases and as a prophylaxis for microscopic malignancies. WBI accelerates brain aging, causing progressive cognitive dysfunction in ~ 50% of surviving p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:GeroScience
Prif Awduron: Yabluchanskiy, Andriy, Tarantini, Stefano, Balasubramanian, Priya, Kiss, Tamas, Csipo, Tamas, Fülöp, Gábor A., Lipecz, Agnes, Ahire, Chetan, DelFavero, Jordan, Nyul-Toth, Adam, Sonntag, William E., Schwartzman, Michal L., Campisi, Judith, Csiszar, Anna, Ungvari, Zoltan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer International Publishing 2020
Pynciau:
ORIGINAL ARTICLE/Understanding Senescence in Brain Aging and Alzheimer’s Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205933/
https://ncbi.nlm.nih.gov/pubmed/31960269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00154-8
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