Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice

Whole brain irradiation (WBI, also known as whole brain radiation therapy or WBRT) is a mainstream therapy for patients with identifiable brain metastases and as a prophylaxis for microscopic malignancies. WBI accelerates brain aging, causing progressive cognitive dysfunction in ~ 50% of surviving p...

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Detalhes bibliográficos
Publicado no:GeroScience
Main Authors: Yabluchanskiy, Andriy, Tarantini, Stefano, Balasubramanian, Priya, Kiss, Tamas, Csipo, Tamas, Fülöp, Gábor A., Lipecz, Agnes, Ahire, Chetan, DelFavero, Jordan, Nyul-Toth, Adam, Sonntag, William E., Schwartzman, Michal L., Campisi, Judith, Csiszar, Anna, Ungvari, Zoltan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
ORIGINAL ARTICLE/Understanding Senescence in Brain Aging and Alzheimer’s Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205933/
https://ncbi.nlm.nih.gov/pubmed/31960269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00154-8
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