Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice

Whole brain irradiation (WBI, also known as whole brain radiation therapy or WBRT) is a mainstream therapy for patients with identifiable brain metastases and as a prophylaxis for microscopic malignancies. WBI accelerates brain aging, causing progressive cognitive dysfunction in ~ 50% of surviving p...

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Udgivet i:GeroScience
Main Authors: Yabluchanskiy, Andriy, Tarantini, Stefano, Balasubramanian, Priya, Kiss, Tamas, Csipo, Tamas, Fülöp, Gábor A., Lipecz, Agnes, Ahire, Chetan, DelFavero, Jordan, Nyul-Toth, Adam, Sonntag, William E., Schwartzman, Michal L., Campisi, Judith, Csiszar, Anna, Ungvari, Zoltan
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2020
Fag:
ORIGINAL ARTICLE/Understanding Senescence in Brain Aging and Alzheimer’s Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205933/
https://ncbi.nlm.nih.gov/pubmed/31960269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00154-8
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