Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging

Adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling (NVC) plays an important role in the maintenance of healthy cognitive function. Strong evidence demonstrates that age-related cerebromicrovascular endothelial dysfunction and consequential impairment of NVC respo...

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Veröffentlicht in:GeroScience
Hauptverfasser: Tarantini, Stefano, Yabluchanskiy, Andriy, Csipo, Tamas, Fulop, Gabor, Kiss, Tamas, Balasubramanian, Priya, DelFavero, Jordan, Ahire, Chetan, Ungvari, Anna, Nyúl-Tóth, Ádám, Farkas, Eszter, Benyo, Zoltan, Tóth, Attila, Csiszar, Anna, Ungvari, Zoltan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885075/
https://ncbi.nlm.nih.gov/pubmed/31679124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-019-00101-2
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