A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval

Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect. However the detection of a stabilized microtubule network needs specific assays since there is not a significant visual difference be...

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Publicat a:Front Pharmacol
Autors principals: Ramirez-Rios, Sacnicte, Michallet, Sophie, Peris, Leticia, Barette, Caroline, Rabat, Clotilde, Feng, Yangbo, Fauvarque, Marie-Odile, Andrieux, Annie, Sadoul, Karin, Lafanechère, Laurence
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204994/
https://ncbi.nlm.nih.gov/pubmed/32425788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00543
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