A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval

Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect. However the detection of a stabilized microtubule network needs specific assays since there is not a significant visual difference be...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Ramirez-Rios, Sacnicte, Michallet, Sophie, Peris, Leticia, Barette, Caroline, Rabat, Clotilde, Feng, Yangbo, Fauvarque, Marie-Odile, Andrieux, Annie, Sadoul, Karin, Lafanechère, Laurence
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204994/
https://ncbi.nlm.nih.gov/pubmed/32425788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00543
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