Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells

Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing, however, adverse effects. To reduce the effective dose of paclitaxel, we searched for pharmaceutics which could potentiate its therapeutic effect. We screened a chemical library and selected Carba1,...

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Detalhes bibliográficos
Main Authors: Lauralie Peronne, Eric Denarier, Ankit Rai, Renaud Prudent, Audrey Vernet, Peggy Suzanne, Sacnicté Ramirez-Rios, Sophie Michallet, Mélanie Guidetti, Julien Vollaire, Daniel Lucena-Agell, Anne-Sophie Ribba, Véronique Josserand, Jean-Luc Coll, Patrick Dallemagne, J. Fernando Díaz, María Ángela Oliva, Karin Sadoul, Anna Akhmanova, Annie Andrieux, Laurence Lafanechère
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-08-01
Colecção:Cancers
Assuntos:
cancer therapy
microtubules
drug synergy
carbazole
paclitaxel
Acesso em linha:https://www.mdpi.com/2072-6694/12/8/2196
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