Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17

The protease ADAM17 (a disintegrin and metalloproteinase 17) catalyzes the shedding of various transmembrane proteins from the surface of cells, including tumor necrosis factor (TNF) and its receptors. Liberation of TNF receptors (TNFRs) from cell surfaces can dampen the cellular response to TNF, a...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Signal
Egile Nagusiak: Maney, Sathish K., McIlwain, David R., Polz, Robin, Pandyra, Aleksandra A., Sundaram, Balamurugan, Wolff, Dorit, Ohishi, Kazuhito, Maretzky, Thorsten, Brooke, Matthew A., Evers, Astrid, Jaguva Vasudevan, Ananda A., Aghaeepour, Nima, Scheller, Jürgen, Münk, Carsten, Häussinger, Dieter, Mak, Tak W., Nolan, Garry P., Kelsell, David P., Blobel, Carl P., Lang, Karl S., Lang, Philipp A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202466/
https://ncbi.nlm.nih.gov/pubmed/26535007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aac5356
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