Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17

The protease ADAM17 (a disintegrin and metalloproteinase 17) catalyzes the shedding of various transmembrane proteins from the surface of cells, including tumor necrosis factor (TNF) and its receptors. Liberation of TNF receptors (TNFRs) from cell surfaces can dampen the cellular response to TNF, a...

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Publicado en:Sci Signal
Main Authors: Maney, Sathish K., McIlwain, David R., Polz, Robin, Pandyra, Aleksandra A., Sundaram, Balamurugan, Wolff, Dorit, Ohishi, Kazuhito, Maretzky, Thorsten, Brooke, Matthew A., Evers, Astrid, Jaguva Vasudevan, Ananda A., Aghaeepour, Nima, Scheller, Jürgen, Münk, Carsten, Häussinger, Dieter, Mak, Tak W., Nolan, Garry P., Kelsell, David P., Blobel, Carl P., Lang, Karl S., Lang, Philipp A.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202466/
https://ncbi.nlm.nih.gov/pubmed/26535007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aac5356
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