iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

Innate immune responses are vital for pathogen defense but can result in septic shock when excessive. A key mediator of septic shock is tumor necrosis factor–α (TNFα), which is shed from the plasma membrane after cleavage by the TNFα convertase (TACE). We report that the rhomboid family member iRhom...

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Publicado no:Science
Main Authors: McIlwain, David R., Lang, Philipp A., Maretzky, Thorsten, Hamada, Koichi, Ohishi, Kazuhito, Maney, Sathish Kumar, Berger, Thorsten, Murthy, Aditya, Duncan, Gordon, Xu, Haifeng C., Lang, Karl S., Häussinger, Dieter, Wakeham, Andrew, Itie-Youten, Annick, Khokha, Rama, Ohashi, Pamela S., Blobel, Carl P., Mak, Tak W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250273/
https://ncbi.nlm.nih.gov/pubmed/22246778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1214448
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