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USP22 controls iNKT immunity through MED1 suppression of histone H2A monoubiquitination

The ubiquitin pathway has been shown to regulate iNKT cell immunity, but the deubiquitinase involved in this process has not been identified. Herein we found that ubiquitin-specific peptidase 22 (USP22) is highly expressed in iNKT cells during their early developmental stage 1. USP22 deficiency bloc...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Zhang, Yana, Wang, Yajun, Gao, Beixue, Sun, Yueqi, Cao, Liang, Genardi, Samantha M., Wang, Chyung-Ru, Li, HuaBin, Sun, Zhaolin, Yang, Yanjie, Fang, Deyu
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201925/
https://ncbi.nlm.nih.gov/pubmed/32069354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182218
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