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USP22 controls iNKT immunity through MED1 suppression of histone H2A monoubiquitination

The ubiquitin pathway has been shown to regulate iNKT cell immunity, but the deubiquitinase involved in this process has not been identified. Herein we found that ubiquitin-specific peptidase 22 (USP22) is highly expressed in iNKT cells during their early developmental stage 1. USP22 deficiency bloc...

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Bibliographische Detailangaben
Veröffentlicht in:J Exp Med
Hauptverfasser: Zhang, Yana, Wang, Yajun, Gao, Beixue, Sun, Yueqi, Cao, Liang, Genardi, Samantha M., Wang, Chyung-Ru, Li, HuaBin, Sun, Zhaolin, Yang, Yanjie, Fang, Deyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201925/
https://ncbi.nlm.nih.gov/pubmed/32069354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182218
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