Histone deacetylase 3 is required for iNKT cell development

NKT cells are a distinct subset that have developmental requirements that often differ from conventional T cells. Here, we show that NKT-specific deletion of Hdac3 results in a severe reduction in the number of iNKT cells, particularly of NKT1 cells. In addition, there is decreased cytokine producti...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Thapa, Puspa, Romero Arocha, Sinibaldo, Chung, Ji Young, Sant’Angelo, Derek B., Shapiro, Virginia Smith
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5517478/
https://ncbi.nlm.nih.gov/pubmed/28724935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06102-5
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