GCN2 drives macrophage and MDSC function and immune suppression in the tumor microenvironment.

GCN2 is an environmental sensor controlling transcription and translation in response to nutrient availability. While GCN2 is a putative therapeutic target for immuno-oncology, its role in shaping the immune response to tumors is poorly understood. Here we used mass cytometry, transcriptomics, and t...

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Gepubliceerd in:Sci Immunol
Hoofdauteurs: Halaby, Marie Jo, Hezaveh, Kebria, Lamorte, Sara, Ciudad, M. Teresa, Kloetgen, Andreas, MacLeod, Bethany L., Guo, Mengdi, Chakravarthy, Ankur, Medina, Tiago Da Silva, Ugel, Stefano, Tsirigos, Aristotelis, Bronte, Vincenzo, Munn, David H., Pugh, Trevor J., DeCarvalho, Daniel D., Butler, Marcus O., Ohashi, Pamela S., Brooks, David G., McGaha, Tracy L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201901/
https://ncbi.nlm.nih.gov/pubmed/31836669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aax8189
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