Apoptotic cell–induced, TLR9-dependent AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans

The transcription factor AhR modulates immunity at multiple levels. Here we report phagocytes exposed to apoptotic cells exhibited rapid activation of AhR, which drove production of interleukin 10. Activation of AhR was dependent on interactions between apoptotic-cell DNA and the pattern-recognition...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Shinde, Rahul, Hezaveh, Kebria, Halaby, Marie Jo, Kloetgen, Andreas, Chakravarthy, Ankur, da Silva Medina, Tiago, Deol, Reema, Manion, Kieran P., Baglaenko, Yuriy, Eldh, Maria, Lamorte, Sara, Wallace, Drew, Chodisetti, Sathi Babu, Ravishankar, Buvana, Liu, Haiyun, Chaudhary, Kapil, Munn, David H., Tsirigos, Aristotelis, Madaio, Michael, Gabrielsson, Susanne, Touma, Zahi, Wither, Joan, De Carvalho, Daniel D., McGaha, Tracy L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976527/
https://ncbi.nlm.nih.gov/pubmed/29760532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0107-1
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