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GCN2-Dependent Metabolic Stress Is Essential for Endotoxemic Cytokine Induction and Pathology

Activated inflammatory macrophages can express indoleamine 2,3-dioxygenase (IDO) and thus actively deplete their own tryptophan supply; however, it is not clear how amino acid depletion influences macrophage behavior in inflammatory environments. In this report, we demonstrate that the stress respon...

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Detalhes bibliográficos
Main Authors: Liu, Haiyun, Huang, Lei, Bradley, Jillian, Liu, Kebin, Bardhan, Kankana, Ron, David, Mellor, Andrew L., Munn, David H., McGaha, Tracy L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911502/
https://ncbi.nlm.nih.gov/pubmed/24248597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00946-13
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