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GCN2-Dependent Metabolic Stress Is Essential for Endotoxemic Cytokine Induction and Pathology
Activated inflammatory macrophages can express indoleamine 2,3-dioxygenase (IDO) and thus actively deplete their own tryptophan supply; however, it is not clear how amino acid depletion influences macrophage behavior in inflammatory environments. In this report, we demonstrate that the stress respon...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3911502/ https://ncbi.nlm.nih.gov/pubmed/24248597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00946-13 |
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